Which of the following cancers is NOT commonly associated with HNPCC?

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Hereditary Nonpolyposis Colorectal Cancer (HNPCC), also known as Lynch syndrome, is primarily linked with an increased risk of several specific cancers. Among these, endometrial, ovarian, and colorectal cancers are some of the most commonly associated malignancies.

Stomach cancer, while less frequently mentioned in connection to HNPCC compared to others, is still recognized as an increased risk in certain studies. Kidney cancer is also noted as part of the spectrum of risk associated with Lynch syndrome.

However, liver cancer does not have a strong or established association with HNPCC. The genetic mutations involved in Lynch syndrome primarily influence the DNA mismatch repair system, but liver cancer has not been commonly reported as an outcome of these mutations. This distinction helps to clarify why liver cancer is characteristically not included in the common associations with HNPCC, making it the correct answer to the question regarding which cancer is not commonly associated with this syndrome.

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