What is a downside of using alcohol injection for tissue ablation?

The downside of using alcohol injection for tissue ablation, particularly pointed out in option B, is that the depth of injury is unpredictable. This unpredictability is significant as it can lead to inadequate treatment of the targeted tissue or unintentional damage to surrounding healthy structures.

When alcohol is injected, it disrupts cellular integrity and dehydrates tissues, causing necrosis. However, the precise depth at which this necrosis occurs can vary based on factors such as the concentration of alcohol used, the volume injected, and the vascularity of the tissue. This variability makes it difficult to judge how effective the treatment will be and what collateral damage might occur, which can complicate clinical decisions and affect patient outcomes.

In addition, while general anesthesia might be preferred for certain procedures, it is not a requirement for alcohol injections, making that option less relevant in this context. Alcohol can be administered through various techniques, including endoscopic methods and others, so the statement about its application being limited to endoscopy is also not accurate. Lastly, while the effectiveness of alcohol on neoplastic tissue may be debated, that does not encompass the primary concern regarding unpredictability of tissue injury. Therefore, the main issue with the use of alcohol injection for tissue ablation highlighted in B directly